Originally from Elmhurst, Illinois, Campbell started his career in film school at Columbia College (Chicago) and went on to the legendary improv-comedy theater, The Second City, where he earned his comedy chops, working alongside, among others, Steve Carell, Bob Odenkirk, and Chris Farley. This led to his film debut in Home Alone (1990).
A role on Fox's Herman's Head (1991) followed, and Campbell's move to Los Angeles was assured. He has appeared in such classic films as Groundhog Day, Armageddon, and in many episodes of television. In 1996, he starred in Local Heroes (1995), a Fox Network sitcom developed by Witt-Thomas Productions. Also a voice talent, he has voiced a wide variety of advertisements, television shows, television cartoons, and will be heard as Boomer the Bear, in Paramount's animated feature, Wonder Park (2019).