No sex or female nudity show in the movie. A man rear nudity show in a shower scene.

A man rear nudity.

There are frequent utterances of the swear word 'f**k' voiced by the main characters out of anger and frustration.

In depicting the extensive doping scheme of Lance Armstrong and his team, the film features frequent references to blood doping and the use of banned performance-enhancing drugs such as EPO, testosterone, and growth hormones.

These references are accompanied by the sight of injections and disposal of the syringes to avoid detection. The athletes are also seen using blood transfusions to ensure a high level of haemoglobin in their blood for increased performance. These scenes of drug use are, however, rather brief, and depicted in the context of performance enhancement.

This film depicts American cycling champion Lance Armstrong's fall from grace, after investigations prove that he had been using performance-enhancing drugs to achieve victories in his races.

As a whole, the film does not encourage substance abuse as the characters involved are seen facing the consequences of their actions, such as being stripped of all their victories, and a coach/physician given a lifetime ban from professional sport.