Python (2000)

Strange murders start occurring in the town of Ruby, Arizona with the victims' corpses left decomposed in acid. At first, the suspicion falls upon John Cooper due to his family being involved in operating a chemical plant and one of the corpses being of his ex-girlfriend. However, it's only after the arrival of defense scientist Dr. Anton Rudolph and Special Agent Parker that the town is faced with the nightmarish reality behind the events: A massive, genetically engineered, 60-foot python. The town must now figure a way to stop the monster, as even the whole of Ruby isn't going to satisfy it's apatite.