Watchers (1988)

Based on a novel by Dean Koontz. An explosion occurs in a classified research laboratory, causing an intense fire. A mutated monster known as the OXCOM (Outside Experimental Combat Mammal) escapes and chases a golden retriever from the same lab, through the surrounding woods. A boy takes in the dog, later discovering that it is super-intelligent due to experiments at the lab, and they both must survive the attacks from the experimental creature.