Charlie gets a physical exam while checking into a rehab facility. He is shown naked from the back, and his butt is clearly shown. He is told to lift up his scrotum, but we only see his hand moving to his front. Quite brief and not sexual.

A hitchhiking youth is tossed out of a car after he steals prescription narcotics.

A college freshman dies of a cocaine overdose after having a seizure on the floor.

Charlie is mugged and beaten; his bloody face is seen.

Frequent strong language ('f**k', 'motherf**ker', 'c**t').

Alcohol, marijuana, cocaine, meth, and heroin are all either discussed or used.

Substance addiction is a main theme of the movie.

A young man struggles with drug addiction, the impasses of his recovery and the devastating impact of his illness on family relationships are shown.