Surgeon Dr. Mira Anand (Tisca Chopra) is scheduled to perform a routine operation on the chief minister, but the night before the procedure, her family is taken hostage and she is ordered to assassinate her unwitting patient in order to save her family, forcing her to make a decision. The story starts a week after season 1. Handa is still under captivity and the whole crew is about to move to Nepal to perform the bone marrow operation. When Handa tries to escape, an unexpected change of plan leads the team to take refuge in a dilapidated old mansion where shooting results in a hostage situation. When new players and motives behind the original plan is revealed more complex situation rises which Prithvi now has to overcome including saving his daughter's life.