Two charecters almost have sex in one episode. They go out to buy condoms and talk to the sales man about sex.
Lillian's last name is Kaushtupper, pronounced cow-schtupper, a homonym/Yiddish wordplay meaning cow-f*cker.
Brief scenes of cleavage and panties.
Overall the show handle's the subjects of sex and sexuality in a non hyper sexualised, very mature way which respects the characters and keeps the content quite PG
During the early episodes of season 3 there is a comedic scene of a woman laying on a table naked covered with food. No nudity is seen.
There are two mentions of heroin in Season 1. Both of them are done by an adult man and we see him taking his clothes off, such as taking his pants down, but nothing explicit or nude happens or is seen; it cuts off into the next scene as he is starting to, and nothing is nude or explicit when we return to the situation.
Some teen girls talk about having sex. Nothing graphic.
Several references to infidelity.
Several characters use the term "hooker" in a comedic way.