Full frontal (animated) nudity is shown in several episodes throughout the show. The moments of nudity are muted by context and lack of visual details.

Many episodes in the final season focus on rape and sexual assault, including towards minors.

It is shown in Season 3 that Dr. Potterswheel is sadistic as he gets sexual gratification from inspecting Bloberta's mutilated vagina and goads her to go further with it, which she does. When she overcomes this bout of depression and stops mutilating herself, he immediately loses interest in her.

The show contains from Moderate to Severe sexual innuendo. The sexual content is infrequent until the episode "God's Chef"; from there, the content slowly becomes more suggestive for the later episodes, especially in Season 3. The show deals with various strong adult themes including masturbation, homosexuality, bisexuality, brief jokes about prostitution, adultery, etc.

It is shown early on that Orel's father, Clay, is having an affair with Coach Stopframe. The relationship is more about their suppressed desires than their acting upon them.

While most violence in the first season is slapstick and humorous, the second and third season include depictions of strong violence, including sexual violence. Although it mostly takes place offscreen, it could still be considered disturbing to many viewers.

There is a scene in an episode where Orel is in a bath tub filled to the brim with blood.

In terms of violence the first season is fairly tame but by the end of season to the show REALLY lives up to its TV-MA.

"Retarded" is said in season 2.

The words "bastard" and "whore" have been used various times, but as with the word "hell", have been used in a logical context. One episode features Orel's father giving the finger.

The misuse of alcohol and drugs are never shown in a positive light, and the dangerous effects of these substances are shown.

Orel's father is seen drinking in every episode, and is seen drunk in a few of the later episodes. Although this is done for comic effect in the first season, it becomes more realistic and disturbing in the later seasons.

Orel smokes a considerable amount of crack/cocaine in the episode Charity; played for comedy, as Orel does not realize the extent of his drug usage.

This is one of the darkest, most mature adult animated shows out there.

The series was cancelled on adult swim for being too dark and depressing.

While starting out as a satirical comedy, it continues to become darker and darker with each passing season, slowly becoming a heavy drama with fairly adult themes.