Incest is a frequent topic. Some of the characters are implied to be sexually active within their family.

Some brief kissing.

Angels are slaughtered. Massive amounts of blood.

Setsuna gets in a fight with some men in a warehouse.

A character has their arm torn off, and tentacles stab them. Massive amounts of blood.

Various characters get serious cuts with massive amounts of blood.

Shit and bastard are used alongside lesser profanity like crap.

Tobacco use and references to unspecified drugs in pill form.

Angels and demons possess various characters, and the entire anime is very anti-religious which may upset particularly sensitive religious viewers.