Slim Shady gave ecstasy to Kyle, Stan, Eric and Kenny. And later, their penises enlarged.
Kyle broflovski uses his penis on a record player.
Eminem is seen having sex with Wendy Testaburger.
Slim Shady is seen having sex with Wendy Testaburger from South Park.
Marshall Mathers was seen raping and having sex with Wendy from South Park.
Cartoon penises and scrotums are seen quite frequently. A very horny teenaged wet dreamer has a dream that he is up in heaven and he grows a boner and a lady giggles. A very brief scene of necrophiliac in "The SlimShank Redemption" sketch and a very brief scene in the penultimate episode where a farmer screws a pig which is shown at an angle.
Violence & Gore
Severe
There is some comic bloody violence. Slim Shady, Knucles and most of the other characters are gangsters.
Profanity
Severe
Frequent colorful selection of swear words like fuck, shit, ass, assface, asshole, pussy, motherfucker, bitch, dick, slut, cock, ho and more.
The word nigga is used too (on rare occasions)
Big D swears the most throughout the show.
Bearing in mind it is Eminem, expect constant very strong language including the f word and the s word.
Alcohol, Drugs & Smoking
Severe
Kenny dies by smoking a bong (probably)
One character use powdered milk as cocaine.
Illegal and dangerous drugs are always present and are a main feature of the series.
Frightening & Intense Scenes
Moderate
This show is not very disturbing but it may offend. "This show makes South Park look like The Smurfs" because of its crude humor.