There are very rare accidental brief moments of partial female buttock exposure, but they aren't shown in a sexual context.

S2 E13: There are three naked men, their private parts are hidden.

Throughout the series, various characters are seen fighting against other characters, like demons. Fight scenes are mild and are done in defense.

Throughout the series, demons and other characters are seen being exploded, impaled, maimed and injured. Injuries tend to be mild with minimal blood shown. The sisters are seen being injured many times but live to fight another day. There are a fair amount of episodes where this is uncertainty if characters are alive or dead. Can be upsetting at times.

A woman is stabbed in the stomach by a man who turns out to be a demon

Demons are killed in fireballs, one is dismembered by having his limbs blown up graphically

Shit is used in some episodes.

Frequent use of profanity such as, ass, bitch, damn, hell, etc.

They drink. Their father smokes cigars.

Sometimes has very intense scenes dealing with death and dying. You see the sisters break down and cry when certain characters die. The actresses are very good, and could easily make the viewers cry as well. Could be hard to watch at times.

Demons fight witches