There is one case of nudity in the whole series.

Big Lez is seen bare naked in his bed in S2 E2. It's the only instance of nudity in the show.

Graphic, bloody, gory animated violence

There are thousands of uses of the word fuck.

The c word is used in season 2 and it's use becomes progressively more frequent, in the final episode of season 3 its used around 90 times.

The swearing is very frequent in this show.

Just the episodes Choomah Island 2 and 3 have over 1,000 uses of the word "fuck"

Frequent, graphic hard drug use throughout.

Frequent drug references to almost every drug in existence

Constant marijuana smoking (joints, bongs, pipes, etc), characters also partake in alcohol, tobacco, cocaine, mushrooms, LSD, heroin, meth, DMT, datura, speed, salvia and a variety of other psychedelic substances.

Lots of fight scenes with screaming and other loud noises that might frighten some.