A character named Jared Shapiro is 30 year old writer (Jake Goldman) dating a kindergartener.

Mild rude humor and some episodes have mildly innuendo.

A man rips his shirt in "Man Up"; the scene it's about a second.

In "Bye Bye, Bellum", the mayor is seen in underwear, the Miss Bellum's sensual voice is heard, and she's partially seen in bikini in the latest seven seconds of the episode.

The episode "Tiara Trouble" contains some very mild suggestive references (like representations of woman, dressing, the spontaneous songs and tiger's appearances).

The episode "Horn, Sweet Horn" have some transgender issues.

A man becomes a centaur in "Blue Ribbon Blues" and he's seen naked but nothing worse than his pectorals is seen.

In "Once Upon a Townsville", Buttercup touches Princess Bluebelle's breasts with a stick, and after they kiss on the mouth accidentally.

In "Man Up 2: Still Man-ing", several people is seen in swimming suits, and a couple is about to kissing. Also the Mayor is seen nude twice with no genitals visible that the Powerpuff Girls see disgusted (except for the first time for Bubbles).

In the short "Bubbles' Beauty Blog but on Video", the Professor is obligated to wear makeup at the end. Also in "Air Buttercup" a kid is seen in underwear briefly.

The girls fight a bevy of villains with cartoon-style violence.

Explosions, crashes, and hand-to-hand fighting are common, with little result other than an occasional black eye or bruise.

The cartoon contains violence, sometimes a little strong, but it is part of the show.

Cartoon fantasy violence, milder to the original series. Sometimes there are visible "red" wounds and black eyes. In "Horn, Sweet Horn", a building is destroyed but is after fixed. In "Strong Armed", buildings being destroyed and moderate punches are seen. Mild weapons are seen and used between fantasy characters. In "Tiara Trouble", a skull is seen, and when Blossom and Buttercup are electrocuted, their skeletons are seen mildly. In "Blue Ribbon Blues", Buttercup kicks a character's butt and Bubbles as a bee enters in his ear and he shouts.

No cursing, but lots of name calling such as "buttzilla" and "butterbutt."

Also talk of whooping a person's butt.

Euphemisms like "darn", "gosh" and "heck" are used. "Screwed up" can be heard as well.

In "Man Up 2: Still Man-ing", Buttercup says: "I know. I screwed up." In "Viral Spiral", "screw up" is said twice, and "suckers" once.

Vague references. In the episode "The Stayover", some children, including the girls, eat so much candy, so they forget what they did.

Monsters of various shapes and sizes can be menacing with scary appearances, large teeth, and abilities such as throwing fire. Some transformation sequences can be scary.

None/Severe for neurodivergent viewers.

The reboot "The Powerpuff Girls" series is more brasher moments than the original series.

The episode "Painbow" can be somewhat scary for younger viewers, specially for the twerk thing, which can upset everyone.