David Arquette built a varied career across film, television, and stage, gaining early recognition through Scream, where his portrayal of Dewey Riley became a defining role revisited across multiple installments. He worked steadily in both studio and independent productions, including Never Been Kissed and Eight Legged Freaks, balancing comedic and dramatic material. Arquette also expanded into directing with The Tripper and has maintained an active presence in theater and documentary projects. His parallel involvement in professional wrestling, highlighted by a run with WCW and later explored in the documentary You Cannot Kill David Arquette, added a distinctive chapter to his creative trajectory.